These non-pharmacologic, non-invasive interventions should be considered by healthcare specialists for elderly patients with early knee OA. Further, reduced levels of inflammatory cytokines were observed. An ISOM + EMS group had the best KOOS score among all groups.Ĭonclusion: Isometric exercise combined with WB-EMS resulted in the best overall improvements in knee function and alleviating the pain and symptoms of patients with early knee OA. ISOM + EMS group resulted in a significant reduction in body weight, fat mass, fat percentage, inflammatory cytokine levels, and increased muscle strength. However, there were significant differences between groups for body composition, muscle strength, KOOS subscale scores, and biomarkers. Results: All variables at pre-intervention showed no significant differences among the three groups. At pre- and post-intervention, anthropometric variables, muscle strength, Knee Injury and Osteoarthritis Outcome Score (KOOS), and blood sampling for biomarkers including interleukin-6, tumor necrosis factor-α, C-reactive protein, and resistin were performed. The main exercises for both groups were performed continuously during the 20 min in an alternation of a 6-s contraction with a 4-s break. The two exercise groups performed their respective programs for 8 weeks, 3 days a week, 30 min a day. Materials and Methods: This randomized controlled study included 75 participants assigned into three groups: the control group (CON), isometric exercise group (ISOM), and isometric exercise and electromyostimulation group (ISOM + EMS). This study examined whether isometric exercise combined with whole body-electromyostimulation (WB-EMS) can improve serum cytokine levels, muscle strength, and knee function in elderly women with early knee OA. Background and Objectives: Muscle strengthening exercise is suggested to beneficial for patients with knee osteoarthritis (OA) and electrical muscular stimulation is reported to be effective in improvement of muscle strength.
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